Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop
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چکیده
منابع مشابه
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop
The inflammasome is an innate immune signaling platform leading to caspase-1 activation, maturation of pro-inflammatory cytokines and cell death. Recognition of DNA within the host cytosol induces the formation of a large complex composed of the AIM2 receptor, the ASC adaptor and the caspase-1 effector. Francisella tularensis, the agent of tularemia, replicates within the host cytosol. The macr...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2013
ISSN: 2235-2988
DOI: 10.3389/fcimb.2013.00014